Veterinary information provided here is not intended as a substitute for direct consultation with a qualified veterinary professional. Afoxolaner is a member of the isoxazoline family, shown to bind at a binding site to inhibit insect and acarine ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NexGard. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. QUALITATIVE AND QUANTITATIVE COMPOSITION. Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)-phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl. Afoxolaner is a member of the isoxazoline class. ®NexGard is a registered trademark, and ™FRONTLINE VET LABS is a trademark, of Merial. In case of accidental ingestion, contact a physician immediately. NexGard contains afoxolaner. NexGard is available in four sizes of beef-flavored soft chewables: 11.3, 28.3, 68 or 136 mg afoxolaner. Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)-phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl. For a copy of the Safety Data Sheet (SDS) or to report suspected adverse drug events, contact Merial at 1-888-637-4251 or www.nexgardfordogs.com. The most frequently reported adverse reaction was vomiting. The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration, redose with another full dose. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). Afoxolaner is recommended to be administered at a dose of 2.7-7 mg/kg dog's bodyweight. Each chewable tablet contains: Active substance: NexGard Afoxolaner (mg) chewable tablets for dogs 2–4 kg 11.3 chewable tablets for dogs >4–10 kg 28.3 chewable tablets for dogs >10–25 kg 68 chewable tablets for dogs >25–50 kg … Every individual animal healthcare product label entry contains a unique identifier which can be used to secure further details directly from the U.S. National Institutes of Health and/or the FDA. Keep this and all drugs out of the reach of children. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. Another dog with a history of seizures had a seizure 19 days after the third dose of NexGard. Not for use in humans. The dog remained enrolled and completed the study. In areas where fleas are common year-round, monthly treatment with NexGard should continue the entire year without interruption. Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses. NexGard (afoxolaner) is for use in dogs only. NexGard ® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea control product. Methods: Client-owned dogs… The dog remained enrolled and completed the study. The majority of dogs have very few side effects from afoxolaner… NEXGARD- afoxolaner tablet, chewableFrontline Vet Labs. At subsequent evaluations post-infestation, fleas from dogs in the treated group were essentially unable to produce any eggs (0-1 eggs) while fleas from dogs in the control group continued to produce eggs (1-141 eggs). In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NexGard. Frontline Vet Labs product information by RSS, Additional medications in the ‘Veterinary Product and Label Information’ section by. Afoxolaner was formulated as a nonmeat‐based chewable dosing form designed for monthly oral administration and was developed and registered as NexGard ®, the first product to effectively control both fleas and ticks on dogs … Afoxolaner kills adult fleas as well as adult ticks. NexGard for dogs 10-24 lbs (Small Dogs 4-10 kg) (Afoxolaner 28.3 mg): Administer one chew per … One tablet dose should be given once a month depending on dog… Copyright © 2021 Animalytix LLC. 1Number of dogs in the afoxolaner treatment group with the identified abnormality. To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea control product. Afoxolaner is used to treat and control flea and tick infestations in dogs. The dog remained enrolled and completed the study. n Mutant/mutant dog, dose … NexGard ® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. NexGard is given orally once a month, at the minimum dosage of 1.14 mg/lb (2.5 mg/kg). The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses. The tablet should always be given as directed by your veterinarian. NexGard (afoxolaner) is for use in dogs only.The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. NexGard (afoxolaner) is for use in dogs only. The safety profile of afoxolaner, a new isoxazoline molecule, was evaluated following the regulatory requirements when administered six times orally in a soft chewable formulation at a dose of at least 1×, 3× or 5× the maximum exposure dose (6.3 mg/kg) in 8-week-old Beagle dogs. Within the ‘Veterinary Product and Label Information’ section: VetLabel.com provides trustworthy package insert and label information about marketed drugs as submitted by manufacturers to the U.S. Food and Drug Administration. NexGard® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. Sometimes afoxolaner is used for the treatment of sarcoptic mange or demodectic mange. There were no clinically-relevant effects related to treatment on physical examination, body weight, food consumption, clinical pathology (hematology, clinical chemistries, or coagulation tests), gross pathology, histopathology or organ weights. Over the 90-day study period, all observations of potential adverse reactions were recorded. CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 2. If a dose is missed, administer NexGard and resume a monthly dosing schedule. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data. The selective toxicity of afoxolaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines’ GABA receptors versus mammalian GABA receptors. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. (2015) Preference of dogs between 2 commercially available oral formulations of ectoparasiticide containing isoxazolines, afoxolaner … … The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Not for use in humans. Each chewable is formulated to provide … In some countries, this medicine may only be approved for veterinary use. Our database mirrors the FDA's central repository of drug labels and package inserts under the Structured Product Labeling standard. Treatment with NexGard may begin at any time of the year. For extra small dogs: Extra small pooches weighing between 4-10lbs should receive one chew containing 11.3mg of Afoxolaner each month. NexGard® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. If a dose is missed, administer NexGard and resume a monthly dosing schedule. Afoxolaner; Orange: Small Dogs: 4 - 10 lbs: 2 to 4 kg: 11.3 mg: Blue: Medium Dogs: 10 - 24 lbs: 4 - 10 kg: 28.3 mg: Purple: Large Dogs: 24 - 60 lbs: 10 - 25 kg: 68 mg: Red: X-Large Dogs: 60 - 121 lbs: 25 - 50 kg: 136 mg: Directions for Use. NexGard 136 mg chewable tablets for dogs >25–50 kg . This dog experienced a third seizure one week after receiving the third dose. Select one or more newsletters to continue. In a well-controlled field study, NexGard was used concomitantly with other medications, such as vaccines, anthelmintics, antibiotics (including topicals), steroids, NSAIDS, anesthetics, and antihistamines. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Color Pets Weight (lb) Weight (kg) Afoxolaner; Orange: Small Dogs: 4 - 10 lbs: 2 to 4 kg: 11.3 mg: Blue: Medium Dogs: 10 - 24 lbs: 4 - 10 kg: 28.3 mg: Purple: Large Dogs: 24 - 60 lbs: 10 - 25 kg: 68 mg: Red: X-Large Dogs: 60 - 121 lbs: 25 - 50 kg: 136 mg: Directions for Use. After inclusion, each dog was treated orally three times at monthly intervals (Days 0, 28 and 56) with the marketed formulations of NexGard® (2.7 mg/kg afoxolaner) or NexGard Spectra® … Keep NexGard in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. Afoxolaner … We offer everyday low prices and excellent customer service to help keep your pet healthy. … There are no known contraindications for the use of NexGard. NexGard can be administered with or without food. Use with caution in dogs … Use with caution in dogs with a history of seizures or neurologic disorders (see Adverse Reactions and Post-Approval Experience). Administer the appropriate combination of chewables. A third dog with a history of seizures received NexGard and experienced no seizures throughout the study. In case of accidental ingestion, contact a physician immediately. The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. https://vetlabel.com/lib/vet/meds/nexgard-1/. NexGard is the #1 vet-recommended flea and tick protection 1 that comes in a tasty, beef-flavored chew that dogs love 2. is the #1 vet-recommended flea and tick protection 1 that comes in a tasty, beef-flavored chew that dogs … Updated: 2020-12-31. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. In a 90-day US field study conducted in households with existing flea infestations of varying severity, the effectiveness of NexGard against fleas on the Day 30, 60 and 90 visits compared with baseline was 98.0%, 99.7%, and 99.9%, respectively. Over the 90-day study period, all observations of potential adverse reactions were recorded. Each chewable size is available in color-coded packages of 1, 3 or 6 beef-flavored chewables. NexGard is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated.Use with caution in dogs … Terms of Use | Copyright © 2021. Background: A multi-centre field trial was conducted to evaluate the efficacy of afoxolaner based chewables (NexGard® or NexGard Spectra®) for the treatment of generalised demodicosis caused by Demodex canis in dogs under field conditions in France, Italy and Poland. The other ingredient Milbemycin oxime is an antiparasitic endectocide. Treatment with NexGard may begin at any time of the year (see Effectiveness). Collectively, the data from the three studies (two laboratory and one field) demonstrate that NexGard kills fleas before they can lay eggs, thus preventing subsequent flea infestations after the start of treatment of existing flea infestations. ... 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