No evidence was found for excretion of 2-butoxyacetic acid, which has been shown to exert haematological effects in rats. The no-effect vapor concentrations for maternal toxicity were 41.1 ppm for rabbits and 20.8 ppm for rats. Later symptoms may include a decreased level of consciousness, headache, and seizures. Ethylene glycol poisoning is poisoning caused by drinking ethylene glycol. Toxicol Lett. Pharmacol. 2-Butoxyethanol is used widely as a solvent in surface coatings, such as spray lacquers, quick-dry lacquers, enamels, varnishes, varnish removers, and latex paint. NIH (NTP, 1992). Ethylene glycol monomethyl ether (EGME) and its acetate ester (EGMEA) are highly flammable, colorless, moderately volatile liquids with very good solubility properties. Levels of airborne 2-butoxyethanol in occupational settings are typically in the mg/m3 range. 1984 Aug;57:7-12. doi: 10.1289/ehp.84577. The effects on the rat testis of single inhalation exposures to ethylene glycol monoalkyl ethers, in particular ethylene glycol monomethyl ether. Based on limited data from case reports and one laboratory study, similar acute effects - including haemolytic effects as well as effects on the central nervous system - are observed in humans and rats exposed to 2-butoxyethanol, although the effects are observed at much higher exposure concentrations in humans than in rats. Many lesions have been described only in morphologic terms and without good clinical histories and laboratory work-ups. Transient eye irritation and barely perceptible skin irritation were among, We tried out the potential irritant and sensitizing effect of the main glycol ethers found in industrial and consumer products. Therefore, the two substances should be considered as equally hazardous to man. The chemical is metabolized primarily via alcohol and aldehyde dehydrogenases, with the formation of 2- butoxyacetaldehyde and 2-butoxyacetic acid, the principal metabolite, although other metabolic pathways have also been identified. Toxicology. 111-76-2) In Support of Summary Information on the . The apparent Michaelis constant range from 0.32 to 0.70 mm while the maximum elimination rate ranged from 0.63 to 1.4 μmol/min/g liver (parallel tube model) in six different experiments. These results indicate that of the chemicals tested only ME, MEA, and MAA are immunosuppressive, and that oxidative metabolism via alcohol dehydrogenase is necessary for ME- and MEA-suppression of the response to TNP-LPS. The in vitro hydrolysis of DGBA in rat blood and its in vivo metabolism and disposition in male Sprague-Dawley rats were studied. review reported a dermal study carried out on 6 adult male rabbits. © 2008-2021 ResearchGate GmbH. On admission the 53-year-old patient was comatose with metabolic acidosis, shock, and noncardiogenic pulmonary edema confirmed by haemodynamic study. The EPA, A poly(dimethylsiloxane) type silicone oil containing gamma-mercaptopropyl groups was evaluated for acute toxicity. 185-191, 1984 Acute and Subchronic Toxicity of Ethylene Glycol Monobutyl Ether by Tipton R. Tyler* The available information on the acute and subchronic toxicity ofethylene glycol monobutyl ether is The absorption of all three glycol ethers was approximately 20–25%, regardless of the chain length of the alkyl group or the dose administered. Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): The available information on the acute and subchronic toxicity of ethylene glycol monobutyl ether is reviewed. Data from animal studies have been examined from the standpoint of dose-response relationships and the sensitivity of various animal species, including man, to the effects of this chemical. Acute toxicity values, such as oral and percutaneous LD 50 s, are often used as the basis for classifying chemicals into toxicity categories, and their subsequent regulation. The contribution of EGME in relation to other exposure factors in the semiconductor industry is unclear. Acute inhalation, oral and dermal toxicity, primary skin irritation, skin sensitization, eye irritation and human patch testing studies failed to demonstrate any significant response to this functional oil. Eb Call fire department ResearchGate to find the people and research you need to help your.. History, and seizures species used in aerosols and cleaning agents intended for household.! Organic arsenicals, especially the herbicide monosodium methanearsonate ( MSMA ) Takasaki W, Mori J. 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